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Transcytosis of IgG01:15

Transcytosis of IgG

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
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Related Experiment Video

Updated: Jul 5, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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[Immunoglobulin A vasculitis].

Sabine Adler1

  • 1Rheumatologie und Immunologie, Kantonsspital Aarau, Tellstraße 25, 5001, Aarau, Schweiz. sabine.adler@ksa.ch.

Innere Medizin (Heidelberg, Germany)
|January 18, 2024
PubMed
Summary
This summary is machine-generated.

IgA vasculitis, or Schoenlein-Henoch purpura, is an immune disorder affecting small vessels. In adults, it presents more severely with skin, joint, GI, and kidney issues, unlike the milder childhood form.

Keywords:
IgA nephritisIgA vasculitis/joint manifestationsIgA vasculitis/skin manifestationsImmunosuppression therapySodium-glucose transporter 2 inhibitors

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Area of Science:

  • Immunology
  • Nephrology
  • Rheumatology

Context:

  • Immune-mediated small vessel vasculitis, known as Schoenlein-Henoch purpura, predominantly affects pediatrics.
  • Adult cases of immunoglobulin A (IgA) vasculitis are more severe, recurrent, and characterized by leukocytoclastic vasculitis, arthritis, gastrointestinal bleeding, and IgA nephritis.

Purpose:

  • To elucidate the pathogenesis of IgA vasculitis, focusing on altered IgA glycosylation leading to immune complex formation.
  • To highlight diagnostic approaches, including histology for leukocytoclastic vasculitis and kidney biopsy for IgA deposits, differentiating it from IgA nephropathy.

Summary:

  • Altered IgA glycosylation is implicated in IgA vasculitis pathogenesis, causing immune complex deposition and neutrophil activation.
  • Diagnosis relies on detecting leukocytoclastic vasculitis and characteristic IgA deposits in kidney biopsies.
  • Treatment is manifestation-specific, incorporating immunosuppression and nephroprotection (e.g., SGLT2 inhibitors) for chronic kidney disease.

Impact:

  • Understanding IgA vasculitis pathogenesis and diagnostic criteria aids in timely and accurate diagnosis.
  • Tailored treatment strategies, including nephroprotection, can improve outcomes for patients with IgA vasculitis, especially those with renal involvement.
  • Recognizing prognostic factors like kidney involvement and potential cardiac manifestations emphasizes the need for continuous patient monitoring.