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Updated: Jul 5, 2025
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
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Circadian clock gene expression and polymorphism in non-segmental vitiligo
Azza Gaber Antar Farag1, Eman A E Badr2, Asmaa Fahmy Ibrahim3
1Andrology and S.T.Ds, Faculty of Medicine, Menoufia University, Shebin AlKom, Egypt.
Molecular Biology Reports
|January 18, 2024
Summary
Circadian gene expression is elevated in non-segmental vitiligo patients, correlating with disease severity and lipid profile changes. Targeting this gene may offer new vitiligo management strategies.
Area of Science:
- Dermatology
- Genetics
- Metabolic Syndrome
Background:
- Vitiligo is an acquired mucocutaneous disease affecting melanocytes.
- Metabolic syndrome is linked to inflammatory skin conditions like vitiligo.
- Circadian dysfunction is implicated in metabolic disease pathogenesis.
Purpose of the Study:
- To investigate the relationship between the aryl hydrocarbon receptor nuclear translocator-like (BMAL1) gene expression and polymorphism with non-segmental vitiligo.
- To assess the impact of BMAL1 on lipid profiles in vitiligo patients.
Main Methods:
- A case-control study involving 50 non-segmental vitiligo patients and 50 controls.
- Analysis included clinical examinations, serum lipid profiles, and measurement of BMAL1 gene expression and rs2279287 polymorphism via real-time PCR.
Main Results:
- Non-segmental vitiligo patients exhibited higher total cholesterol, triglyceride, and LDL, with lower HDL.
- Elevated BMAL1 gene expression was observed in vitiligo patients, with a higher prevalence of the T/C genotype.
- BMAL1 levels correlated positively with patient age, age of onset, and VIDA Score, and could predict vitiligo prognosis.
Conclusions:
- The circadian gene (BMAL1) plays a role in non-segmental vitiligo progression.
- Targeting BMAL1 presents a potential therapeutic avenue for vitiligo management.
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