Toward a solid microneedle patch for rapid and enhanced local analgesic action

Area of Science:

• Biomaterials Science
• Dermatology
• Pharmacology

Background:

• Analgesic creams have limited efficacy due to slow skin penetration.
• Prolonged waiting times for localized anesthesia impact patient compliance and workflow.

Purpose of the Study:

• To develop a microneedle (MN) patch for enhanced intradermal lidocaine delivery.
• To achieve rapid and effective local anesthesia using a minimally invasive approach.

Main Methods:

• Biodegradable polylactic acid (PLA) MNs were fabricated using hot-pressing.
• MN morphology and mechanical strength were assessed via microscopy and penetration tests.
• Efficacy was evaluated on porcine skin, artificial films, OCT, and live rats using behavioral pain tests.

Main Results:

• PLA MNs demonstrated robust mechanical strength for effective skin penetration.
• MN-assisted lidocaine treatment reduced anesthesia onset from 40 to 10 minutes.
• Treatment parameters like drug sequence and MN dimensions influenced anesthesia efficacy.

Conclusions:

• PLA microneedle patches offer a promising strategy for rapid clinical local anesthesia.
• This approach enhances lidocaine cream delivery for improved patient outcomes and workflow efficiency.