Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

344
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
344
Analgesia and Pain Management01:25

Analgesia and Pain Management

625
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
625
Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

448
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
448
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1.1K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LUX ARRHYTHMO transcription factors regulate photoperiod-mediated resistance against common cutworm in soybean.

Journal of integrative plant biology·2026
Same author

Carbon dot crosslinked hydrogel with microenvironment modulation for wound healing via synergistic antibacterial, antioxidant and hypoxia mitigation.

Colloids and surfaces. B, Biointerfaces·2026
Same author

Pharmacological Exploration of Traditional Chinese Medicine and Tujia Ethnomedicine in Rheumatoid Arthritis Therapy: From Historical Clinical Wisdom to Contemporary Scientific Inquiry.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Cross-linked recombinant type III collagen hydrogel for prevention of intrauterine adhesions.

International journal of biological macromolecules·2026
Same author

Driving safety evaluation for hazardous materials vehicle drivers based on visual characteristics.

Traffic injury prevention·2026
Same author

Correction to "Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment".

ACS applied materials & interfaces·2026

Related Experiment Video

Updated: Jul 5, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.2K

Toward a solid microneedle patch for rapid and enhanced local analgesic action.

Yue Liu1,2, Ze Qiang Zhao1,2, Ling Liang1,2

  • 1State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, China.

Drug Delivery and Translational Research
|January 18, 2024
PubMed
Summary

Biodegradable microneedles (MNs) enhance lidocaine cream delivery for faster local anesthesia. This minimally invasive patch accelerates pain relief onset from 40 to 10 minutes, improving patient and clinician efficiency.

Keywords:
Anagesic effectBiodegradable microneedlesLidocainePain management

More Related Videos

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
07:41

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability

Published on: July 12, 2024

2.2K
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

14.4K
Polymeric Microneedle Array Fabrication by Photolithography
08:15

Polymeric Microneedle Array Fabrication by Photolithography

Published on: November 17, 2015

12.1K

Area of Science:

  • Biomaterials Science
  • Dermatology
  • Pharmacology

Background:

  • Analgesic creams have limited efficacy due to slow skin penetration.
  • Prolonged waiting times for localized anesthesia impact patient compliance and workflow.

Purpose of the Study:

  • To develop a microneedle (MN) patch for enhanced intradermal lidocaine delivery.
  • To achieve rapid and effective local anesthesia using a minimally invasive approach.

Main Methods:

  • Biodegradable polylactic acid (PLA) MNs were fabricated using hot-pressing.
  • MN morphology and mechanical strength were assessed via microscopy and penetration tests.
  • Efficacy was evaluated on porcine skin, artificial films, OCT, and live rats using behavioral pain tests.

Main Results:

  • PLA MNs demonstrated robust mechanical strength for effective skin penetration.
  • MN-assisted lidocaine treatment reduced anesthesia onset from 40 to 10 minutes.
  • Treatment parameters like drug sequence and MN dimensions influenced anesthesia efficacy.

Conclusions:

  • PLA microneedle patches offer a promising strategy for rapid clinical local anesthesia.
  • This approach enhances lidocaine cream delivery for improved patient outcomes and workflow efficiency.