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Pulmonary arterial hypertension and COVID-19: Piecing the puzzle

Fida Charif1, Fatima Dakroub2, Imad Bou Akl3

  • 1Pulmonology Division, Hopitaux du Léman, Thonon les bains, France.

Respiratory Medicine and Research
|January 18, 2024
PubMed

Insights

Despite the pandemic

Area of Science:

  • Cardiology and Infectious Diseases

Background:

  • COVID-19 poses risks for cardiovascular disease (CVD) patients.
  • Pulmonary arterial hypertension (PAH) patients have shown varied COVID-19 outcomes.
  • This review addresses COVID-19 in PAH patients.

Approach:

  • Summarizing current literature on COVID-19 clinical presentation in PAH.
  • Discussing shared pathology and disease mechanisms between PAH and COVID-19.
  • Reviewing PAH therapies for potential COVID-19 treatment.

Key Points:

  • COVID-19 clinical characteristics in PAH patients are not fully understood.
  • PAH and COVID-19 share pathological pathways.
  • Existing PAH therapies may offer treatment avenues for COVID-19.

Conclusions:

  • Further research is needed to clarify COVID-19's impact on PAH patients.
  • Investigating PAH-approved drugs for COVID-19 treatment efficacy and safety is crucial.
  • Prospective studies are proposed to guide future clinical practice.

Keywords:
COVID-19Clinical coursePAH-COVID-19 interactionPAH-approved therapyPulmonary arterial hypertension

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