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Virtual dosimetry study with three cone-beam breast computed tomography scanners using a fast GPU-based Monte Carlo

Giovanni Mettivier^1,2, Youfang Lai³, Xun Jia⁴

¹Dipartimento di Fisica 'Ettore Pancini', Università di Napoli Federico II, I-80126 Naples, Italy.

Physics in Medicine and Biology

|January 18, 2024

Summary

This study compared cone-beam breast CT (BCT) scanner dosimetry using a GPU-accelerated Monte Carlo platform. Lower tube voltages (49 kV) resulted in less uniform glandular dose distribution compared to higher voltages (80 kV, 60 kV).

Keywords:

GPU Monte Carlo simulations breast computed tomography virtual clinical trials

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Area of Science:

Medical Physics
Radiological Imaging
Computational Dosimetry

Background:

Accurate dose estimation is crucial for optimizing breast imaging protocols.
Cone-beam breast computed tomography (BCT) offers advanced imaging capabilities but requires dosimetric evaluation.
Virtual clinical trials (VCT) provide a powerful tool for simulating and analyzing imaging scenarios.

Purpose of the Study:

To compare the dosimetric performance of three BCT scanners using a novel GPU-accelerated Monte Carlo (MC) platform.
To evaluate the impact of different tube voltages on dose distribution uniformity in virtual breast phantoms.
To validate the VCT-BREAST platform for real-time dosimetry and imaging trials in BCT.

Main Methods:

Developed a GPU-based MC code to simulate BCT scanner geometries, spectra, and detector setups.
Utilized 16 anthropomorphic voxelized breast phantoms for virtual BCT examinations.
Simulated dose maps at various tube voltages (80 kV, 60 kV, 49 kV) and compared dose distribution spread.

Main Results:

Glandular dose distribution was more uniform in less dense breasts.
Scans at 80 kV and 60 kV demonstrated more uniform dose distribution compared to 49 kV.
The VCT-BREAST platform achieved high accuracy (<1% uncertainty) and efficiency (3.0 hours per phantom).

Conclusions:

The VCT-BREAST platform enables fast and accurate real-time dosimetry for BCT.
Tube voltage significantly influences dose distribution uniformity, with lower voltages potentially leading to less uniform doses.
This simulation tool can guide the optimization of BCT scanner parameters for improved dose delivery.