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Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
12.0K
Capillary electrophoresis separations with deep eutectic solvents as greener separation media: A proof-of-concept
Sihui Ding1, Yu Xu1, Song Xue2
1School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China.
Journal of Chromatography. A
|January 18, 2024
Summary
This study introduces deep eutectic solvents (DESs) as novel, eco-friendly media for capillary electrophoresis (CE). DESs offer a greener alternative to hazardous organic solvents for effective separation of complex mixtures.
Area of Science:
- Analytical Chemistry
- Separation Science
- Green Chemistry
Background:
- Capillary electrophoresis (CE) traditionally uses aqueous or hazardous non-aqueous organic solvents.
- There is a need for environmentally benign and safer alternatives in CE separation media.
Purpose of the Study:
- To introduce deep eutectic solvents (DESs) as novel, environmentally friendly media for CE.
- To investigate the fundamental properties and separation capabilities of DES-based CE systems.
Main Methods:
- Utilized a proline and urea (Proline:Urea, PU) based DES as the separation medium.
- Evaluated DES properties: thermal, viscosity, electroconductivity, and detector compatibility.
- Performed separations using capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) modes.
Main Results:
- Successfully separated a complex mixture of ten naphthalene-based compounds using DES-CZE.
- Developed a DES-MEKC system with Tween-20 to resolve six structurally similar naphthalene isomers.
- Demonstrated the effectiveness of DESs in achieving separations not possible with CZE.
Conclusions:
- Deep eutectic solvents (DESs) are viable, green alternatives to organic solvents in CE.
- DESs offer tunable properties suitable for both CZE and MEKC applications.
- This work highlights the potential of DESs for sustainable and efficient electrophoretic separations.
Keywords:
Capillary electrophoresisDeep eutectic solventGreen chemistryMicellar electrokinetic chromatographySeparation mediumMore Related Videos
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