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Updated: Jul 5, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
SIRT1 regulates endoplasmic reticulum stress-related organ damage
He Hu1, Weichao Xu2, Yan Li1
1Hebei University of Chinese Medicine, Shijiazhuang, China.
Abstract:
Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several organ damages. Studies show that excessive ER stress (ERS) can destroy cellular homeostasis, causing cell damage and physiological dysfunction in various organs. In recent years, Sirtuin1 (SIRT1) has become a research hotspot on ERS. Increasing evidence suggests that SIRT1 plays a positive role in various ERS-induced organ damage via multiple mechanisms, including inhibiting cellular apoptosis and promoting autophagy. SIRT1 can also alleviate liver, heart, lung, kidney, and intestinal damage by inhibiting ERS. We discuss the possible mechanism of SIRT1, explore potential therapeutic targets of diseases, and provide a theoretical basis for treating ERS-related diseases.
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