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Related Concept Videos

Thermosensation01:43

Thermosensation

30.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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PID Controller01:19

PID Controller

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Proportional-Integral-Derivative (PID) controllers are widely used in various control systems to enhance stability and performance. In a thermostat, it adjusts heating or cooling based on the temperature difference between the actual and desired levels. They are often used in automotive speed systems, effectively managing sudden speed changes while maintaining a constant speed under varying conditions. On the other hand, PI controllers, commonly employed in voltage regulation, enhance stability...
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Body Temperature01:25

Body Temperature

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The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
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Assessing Body Temperature - Tympanic membrane01:14

Assessing Body Temperature - Tympanic membrane

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Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
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Articles linked to this work by shared authors, journal, and citation graph.

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Ca<sup>2+</sup> trapping by allosteric coupling explains species differences in TRPM2 inactivation reversibility.

Communications biology·2026
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Evolution of Temperature Dependence of TRPM2 Channel Gating and Inactivation in Vertebrates.

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Altered functional interactions between CFTR disease mutants ΔF508 and G551D and the protein kinase A catalytic subunit.

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Molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the CFTR channel.

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Direct Assessment of Temperature Sensitivity of the TRPM2 Channel with the Patch Clamp Technique.

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A conserved mechanism couples cytosolic domain movements to pore gating in the TRPM2 channel.

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Related Experiment Video

Updated: Jul 5, 2025

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

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TRPM2 - An adjustable thermostat.

Ádám Bartók1, László Csanády1

  • 1Department of Biochemistry, Semmelweis University, Budapest, Hungary; HCEMM-SE Molecular Channelopathies Research Group, Budapest, Hungary; HUN-REN-SE Ion Channel Research Group, Budapest, Hungary.

Cell Calcium
|January 18, 2024
PubMed
Summary

The Transient Receptor Potential Melastatin 2 (TRPM2) channel

Area of Science:

  • Biophysics
  • Molecular Biology
  • Physiology

Background:

  • The TRPM2 channel is a ligand-gated cation channel sensitive to temperature.
  • TRPM2 plays roles in thermosensation, insulin secretion, and immune function.
  • Mechanisms underlying TRPM2 temperature sensitivity are debated.

Purpose of the Study:

  • To review TRPM2 temperature sensitivity.
  • To focus on mechanistic insights from cell-free systems.
  • To reconcile in vivo and in vitro findings.

Main Methods:

  • Literature review
  • Analysis of biophysical data from cell-free systems
  • Interpretation of intact cell studies

Main Results:

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Thermal Limits Determination for Zooplankton Using a Heat Block

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Related Experiment Videos

Last Updated: Jul 5, 2025

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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  • TRPM2 exhibits an endothermic opening transition.
  • Temperature threshold is modulated by ADPR and Ca2+.
  • Ca2+ influx creates a positive feedback loop enhancing response steepness.

Conclusions:

  • TRPM2 has intrinsic biophysical properties governing its temperature sensitivity.
  • Cell-free data explain complex intact cell observations.
  • Understanding TRPM2 function requires considering its intrinsic properties.