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Updated: Jul 5, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
Published on: June 6, 2025
SARS-CoV-2-Virus structure and life cycle
Sameer Saleem Tebha1, Aimen Tameezuddin2, Sanchit Bajpai3
1Jinnah Medical and Dental College, Karachi, Pakistan; Department of Research, Larkins Community Hospital, South Miami, Florida, USA.
Abstract:
This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses, the SARS-CoV-2 structure including the structural as well as nonstructural proteins in detail, and the viral replication mechanisms. The chapter then delves into the characteristics and diversity of coronaviruses, particularly SARS-CoV-2, highlighting its similarities with other beta-coronaviruses. The replication and transcription complex, RNA elongation, and capping, as well as the role of accessory proteins in viral replication and modulation of the host immune response is discussed extensively.
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