Related Experiment Video
Updated: Jul 5, 2025
09:26
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
Published on: June 6, 2025
170
COVID-19 pathogenesis
Asiya Kamber Zaidi1, Rohan Bir Singh2, Syed A A Rizvi3
1ENT Surgeon and Research Fellow, Associazione Naso Sano, Italy.
Progress in Molecular Biology and Translational Science
|January 18, 2024
Summary
COVID-19 pathogenesis involves SARS-CoV-2 and host factors, causing multisystem effects beyond the lungs. Understanding these extrapulmonary manifestations and their mechanisms is crucial for comprehensive disease management.
Area of Science:
- Virology
- Immunology
- Pathology
Background:
- COVID-19, caused by SARS-CoV-2, presents complex pathogenesis.
- Disease manifestations extend beyond the respiratory system, involving multiple organs.
Purpose of the Study:
- To provide an overview of COVID-19 risk factors, genetic predispositions, and multisystem manifestations.
- To elucidate the mechanisms underlying extrapulmonary disease.
- To detail COVID-19's impact across various organ systems.
Main Methods:
- Review of current literature on SARS-CoV-2 pathogenesis.
- Analysis of direct viral invasion and indirect pathogenic mechanisms.
- Detailed examination of organ-specific clinical presentations.
Main Results:
- SARS-CoV-2 directly invades organs and causes indirect damage via RAAS dysregulation, immune dysfunction, endothelial damage, and immunothrombosis.
- Extrapulmonary manifestations are observed across cardiovascular, renal, gastrointestinal, nervous, endocrine, and other systems.
- Each organ system exhibits distinct clinical features contributing to disease complexity.
Conclusions:
- COVID-19 is a multisystem disease with diverse extrapulmonary manifestations.
- Understanding these complex interactions is key to managing COVID-19's full spectrum.
- Further research into specific organ system impacts is warranted.
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