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Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

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Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Related Experiment Video

Updated: Jul 5, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
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COVID-19 pathogenesis.

Asiya Kamber Zaidi1, Rohan Bir Singh2, Syed A A Rizvi3

  • 1ENT Surgeon and Research Fellow, Associazione Naso Sano, Italy.

Progress in Molecular Biology and Translational Science
|January 18, 2024
PubMed
Summary
This summary is machine-generated.

COVID-19 pathogenesis involves SARS-CoV-2 and host factors, causing multisystem effects beyond the lungs. Understanding these extrapulmonary manifestations and their mechanisms is crucial for comprehensive disease management.

Keywords:
ARDSExtrapulmonary symptomsImmune dysregulationMultiorgan manifestations

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Area of Science:

  • Virology
  • Immunology
  • Pathology

Background:

  • COVID-19, caused by SARS-CoV-2, presents complex pathogenesis.
  • Disease manifestations extend beyond the respiratory system, involving multiple organs.

Purpose of the Study:

  • To provide an overview of COVID-19 risk factors, genetic predispositions, and multisystem manifestations.
  • To elucidate the mechanisms underlying extrapulmonary disease.
  • To detail COVID-19's impact across various organ systems.

Main Methods:

  • Review of current literature on SARS-CoV-2 pathogenesis.
  • Analysis of direct viral invasion and indirect pathogenic mechanisms.
  • Detailed examination of organ-specific clinical presentations.

Main Results:

  • SARS-CoV-2 directly invades organs and causes indirect damage via RAAS dysregulation, immune dysfunction, endothelial damage, and immunothrombosis.
  • Extrapulmonary manifestations are observed across cardiovascular, renal, gastrointestinal, nervous, endocrine, and other systems.
  • Each organ system exhibits distinct clinical features contributing to disease complexity.

Conclusions:

  • COVID-19 is a multisystem disease with diverse extrapulmonary manifestations.
  • Understanding these complex interactions is key to managing COVID-19's full spectrum.
  • Further research into specific organ system impacts is warranted.