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[Strategies for liver injury caused by hepatocellular carcinoma targeted therapy]

S X Zhao1, S H Liu1, Y M Nan1

  • 1Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, the Key Laboratory of Hepatic Fibrosis Mechanisms of Chronic Liver Diseases in Hebei Province, Hebei International Science and Technology Cooperation Base -- Hebei International Joint Research Center for Molecular Diagnosis of Liver Cancer, Shijiazhuang 050051, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology
|January 19, 2024
PubMed

Insights

Hepatocellular carcinoma targeted therapy offers new hope for advanced liver cancer. However, liver injury is a common side effect requiring careful management for safe treatment.

Area of Science:

  • Oncology
  • Hepatology
  • Pharmacology

Context:

  • Primary hepatocellular carcinoma (HCC) is a highly malignant liver cancer with insidious onset and rapid progression.
  • Molecular targeted drugs represent a significant advancement in treating advanced HCC.
  • Liver injury is a frequent adverse event associated with these targeted therapies.

Purpose:

  • To review the occurrence, mechanisms, risk factors, diagnosis, and management of liver injury induced by HCC targeted therapy.
  • To provide a clinical reference for the safe and effective use of targeted drugs in HCC patients.

Summary:

  • Hepatocellular carcinoma targeted therapy, while promising for advanced disease, is associated with a notable risk of drug-induced liver injury (DILI).
  • Understanding the conditions, mechanisms, and risk factors for DILI is crucial for early detection and intervention.
  • This review synthesizes current knowledge on diagnosing and managing liver injury in patients undergoing targeted treatment for HCC.

Impact:

  • Facilitates safer clinical application of molecular targeted drugs in advanced liver cancer.
  • Improves patient outcomes by enabling proactive management of treatment-related toxicities.
  • Highlights the importance of monitoring liver function during targeted therapy for HCC.
Keywords:
Drug-induced liver injuryHepatocellular carcinomaTargeted therapy

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