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Updated: Jul 5, 2025
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
[Research progress on AMPK activation in nonalcoholic fatty liver disease]
1Department of General Surgery (Hepatopancreatobiliary Surgery), the First Affiliated Hospital of Southwest Medical University & Academician (Expert) Workstation of Sichuan Province, the First Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
None:
Nonalcoholic fatty liver disease (NAFLD) occurrence and progression are associated with lipid accumulation, insulin resistance, inflammation, liver damage, fibrosis, and other factors. AMP-dependent protein kinase (AMPK) is a key molecule that regulates bioenergy metabolism and participates in multiple biological processes, including lipid metabolism, autophagy, inflammation, and cell apoptosis. Promoting AMPK activation can reduce hepatic lipid accumulation and insulin resistance, alleviate the development of NAFLD, reduce liver inflammation and fibrosis, and inhibit the progression of NAFLD to nonalcoholic steatohepatitis.
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