Related Experiment Video
Updated: Jul 5, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
Published on: October 25, 2024
Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on
Carolina Brescia1,2, Salvatore Audia1,2, Alessia Pugliano1,2
1Department of Health Science, Medical School, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Abstract:
The CD4+ T-cell population plays a vital role in the adaptive immune system by coordinating the immune response against different pathogens. A significant transformation occurs in CD4+ cells during an immune response, as they shift from a dormant state to an active state. This transformation leads to extensive proliferation, differentiation, and cytokine production, which contribute to regulating and coordinating the immune response. Th17 and Treg cells are among the most intriguing CD4+ T-cell subpopulations in terms of genetics and metabolism. Gene expression modulation processes rely on and are linked to metabolic changes in cells. Lactylation is a new model that combines metabolism and gene modulation to drive Th17/Treg differentiation and functional processes. The focus of this review is on the metabolic pathways that impact lymphocyte gene modulation in a functionally relevant manner.
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
The Tumor Microenvironment
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...

