Related Experiment Video
Updated: Jul 5, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Comparison of computer controlled local anesthetic delivery and traditional injection regarding disruptive behaviour,
1Department of Pedodontics, Gaziantep University, Faculty of Dentistry, 27560 Gaziantep, Turkey.
Insights
Computer-controlled local analgesic delivery (CCLAD) significantly reduced pain and anxiety in children compared to traditional injections. This method is recommended for pediatric patients undergoing dental procedures.
Area of Science:
- Pediatric Dentistry
- Anesthesiology
- Pain Management
Background:
- Infiltrative anesthesia administration methods can influence patient comfort and anxiety levels.
- Assessing pain and anxiety in children requires multi-modal approaches, including psychometric, physiological, and biochemical indicators.
Purpose of the Study:
- To compare the efficacy of computer-controlled local analgesic delivery (CCLAD) versus traditional injection methods in reducing pain and anxiety in pediatric patients.
- To evaluate the impact of different anesthesia delivery methods on physiological and biochemical markers of stress.
Main Methods:
- A study involving 60 children aged 7-11 years, divided into a control group (traditional injection) and a study group (CCLAD).
- Pain and anxiety were measured using the Visual Analogue Scale (VAS), Wong-Baker Faces Rating Pain Scale (WBS), Modified Child Dental Anxiety Scale (MCDAS), and Face, Leg, Activity, Cry, Consolability (FLACC) scale.
- Physiological (pulse, SpO2) and biochemical (salivary cortisol) parameters were monitored.
Main Results:
- While SpO2 levels did not differ significantly between groups, the control group showed increased pulse, VAS, WBS, MCDAS, FLACC scores, and salivary cortisol post-anesthesia.
- The CCLAD group demonstrated decreased WBS, MCDAS, FLACC scores, and salivary cortisol levels compared to the control group (p < 0.05).
Conclusions:
- Computer-controlled local analgesic delivery (CCLAD) is a superior method for managing pain and anxiety in pediatric dental patients.
- CCLAD offers a more comfortable and less stressful alternative to traditional injections for infiltrative anesthesia in children.
Abstract:
The study herein evaluated the effects of infiltrative anesthesia administered via different ways. Resultantly, the pain and anxiety were monitored using psychometric, physiological and biochemical methods. Sixty children aged 7-11 years (8.73 ± 1.38) were included in the study. They were divided into 2 groups (n = 30): Traditional injection (control group), and computer controlled local analgesic delivery (CCLAD) (study group). Pulse, oxygen saturation (SpO2), and salivary cortisol levels were recorded, and the scales data (Visual Analogue Scale (VAS), Wong-Baker Faces Rating Pain Scale (WBS), Modified Child Dental Anxiety Scale (MCDAS) and Face, Leg, Activity, Cry, Consolability Behavioral Pain Assessment Scale (FLACC)) were evaluated. The data were statistically analyzed. Age and gender had not much impact on the measured parameters (p > 0.05). SpO2 values in both groups were not significantly different (p > 0.05). Pulse, VAS, WBS, MCDAS, FLACC and salivary cortisol values were increased after the anesthesia in control group (p < 0.05). WBS, MCDAS, FLACC and salivary cortisol values were decreased after the anesthesia in study group compared to the control (p < 0.05). It was inferred that computer controlled local analgesic delivery system could be preferred in pediatric patients because of reduced pain and anxiety.
Related Concept Videos
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia
Local Anesthetics: Pharmacokinetics
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Local Anesthetics: Chemistry and Structure-Activity Relationship

