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One-Dimensional HKUST-1-Decorated Glassy Carbon Electrode for the Sensitive Electrochemical Immunosensor of NS1
Kariana Kusuma Dewi1,2, Ni Luh Wulan Septiani1,3,2, Shofarul Wustoni4
1Advanced Functional Materials Laboratory, Faculty of Industrial Technology, Institut Teknologi Bandung, Bandung 40132, Indonesia.
Abstract:
In this work, simple and sensitive detection of dengue virus serotype-3 (DENV-3) antigen was accomplished by a one-dimensional (1D) HKUST-1-functionalized electrochemical sensor. 1D HKUST-1 was synthesized via a coprecipitation method using triethanolamine (TEOA) as pH modulator and structure-directing agent. The structure, morphology, and sensing performance of the HKUST-1-decorated carbon electrode were characterized by X-ray diffraction (XRD), infrared spectroscopy (FTIR), scanning electron microscopy (SEM), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). We found that 40 wt% TEOA transforms the octahedron HKUST-1 to the nanorods while maintaining its crystal structure and providing chemical stability. The 1D HKUST-1-decorated carbon electrode successfully detects the antigen in the range of 0.001-10 ng/mL with a detection limit of 0.932 pg/mL. The immunosensor also exhibits remarkable performance in analyzing the antigen in human serum and showed recovery as high as ∼98% with excellent selectivity and reproducibility.
