Recent advances in natural compounds inducing non-apoptotic cell death for anticancer drug resistance

Area of Science:

• Oncology
• Molecular Biology
• Pharmacology

Background:

• Apoptosis evasion is a key mechanism of cancer drug resistance.
• Novel therapeutic strategies are needed to overcome treatment failures.
• Non-apoptotic cell death pathways offer alternative targets for cancer therapy.

Purpose of the Study:

• To review recent advancements in non-apoptotic cell death mechanisms (ferroptosis, necroptosis, pyroptosis, paraptosis) for cancer treatment.
• To highlight the role of natural compounds in overcoming cancer drug resistance.
• To explore the potential of natural compounds in inducing these alternative cell death pathways.

Main Methods:

• Literature review of studies on non-apoptotic cell death.
• Analysis of research on natural compounds with anticancer properties.
• Synthesis of findings regarding the induction of ferroptosis, necroptosis, pyroptosis, and paraptosis by natural products.

Main Results:

• Natural compounds can effectively induce ferroptosis, necroptosis, pyroptosis, and paraptosis.
• These mechanisms provide alternative routes to eliminate cancer cells resistant to apoptosis.
• Numerous natural compounds demonstrate significant anticancer and anti-resistance effects.

Conclusions:

• Non-apoptotic cell death pathways are promising strategies to combat cancer drug resistance.
• Natural compounds represent a valuable resource for developing novel anti-cancer therapies that bypass resistance.
• Targeting these alternative cell death mechanisms with natural products offers a viable approach to enhance cancer treatment efficacy.