Postoperative systemic inflammatory response syndrome predicts increased mortality in patients after elective...

Area of Science:

• Neurosurgery
• Critical Care Medicine
• Inflammatory Response

Background:

• Craniotomy patients face significant risks from exaggerated inflammatory responses.
• Systemic Inflammatory Response Syndrome (SIRS) is a common complication post-craniotomy.

Purpose of the Study:

• To assess the prognostic value of postoperative SIRS in craniotomy patients.
• To determine the association between SIRS and 30-day mortality after craniotomy.

Main Methods:

• Retrospective cohort study of 12,887 craniotomy patients (Jan 2011-Mar 2021).
• SIRS diagnosis based on hypo-/hyperthermia, tachypnea, leukopenia/leukocytosis, or tachycardia.
• Univariate and multivariate analyses examined SIRS development and 30-day mortality.

Main Results:

• Over half (52.2%) developed SIRS; 1.22% experienced 30-day mortality.
• SIRS was independently associated with 30-day mortality (OR, 1.57).
• Delayed SIRS, not early SIRS, predicted mortality; elevated WBC counts were the main contributor.

Conclusions:

• Postoperative SIRS is a frequent and independent predictor of 30-day mortality in craniotomy patients.
• The predictive value of SIRS is significant only for delayed onset.
• Abnormal white blood cell counts are the most influential factor in SIRS development post-craniotomy.