Related Experiment Video
Updated: Jul 5, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
[Retracted] Effect of RhoC on the epithelial‑mesenchymal transition process induced by TGF‑β1 in lung adenocarcinoma
Xiaoxiao Lu1, Honglan Guo1, Xi Chen2
1Department of Geriatrics, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China.
Abstract:
Following the publication of the above article, a concerned reader drew to the Editor's attention that the Transwell cell invasion assay data featured in Figs. 3 and 5, and the cell microscopic/morphological images shown in Fig. 4A and C, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Oncology Reports, or which under consideration for publication at around the same time (several of which have now been retracted). In addition, overlapping sections of data were noted within Figs. 3 and 5, such that data which were intended to represent the results from differently performed experiments had apparently been derived from the same original source(s). In view of the fact that certain of these data had already apparently been published prior to the submission of this article for publication, the Editor of Oncology Reports has decided that this paper should be retracted from the Journal. After having been in contact with the authors, they agreed with the decision to retract the paper. The Editor apologizes to the readership for any inconvenience caused. [Oncology Reports 36: 3105‑3112, 2016; DOI: 10.3892/or.2016.5146].
Related Concept Videos
TGF - β Signaling Pathway
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Cell Polarization by Rho Proteins
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

