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The compression-only behavior of coated microbubbles in a wall restricted flow.

Maria Vlachomitrou¹, Nikos Pelekasis¹

¹Department of Mechanical Engineering, University of Thessaly, Leoforos Athinon, Pedion Areos, 38334 Volos, Greece.

The Journal of the Acoustical Society of America

|January 19, 2024

Summary

The study numerically investigates lipid shelled contrast agents near a rigid wall. Wall proximity alters bubble dynamics, influencing compression-only behavior and entrapment under acoustic waves.

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Area of Science:

Acoustic cavitation
Biomedical engineering
Fluid dynamics

Background:

Lipid shelled contrast agents are crucial in medical ultrasound.
Understanding their behavior near surfaces is key for targeted drug delivery.
Acoustic forces can induce unique dynamic responses in these agents.

Purpose of the Study:

To numerically investigate the compression-only behavior of lipid shelled contrast agents near a rigid wall.
To analyze the dynamic interaction under acoustic disturbances.
To map the parameter space influencing bubble response.

Main Methods:

Numerical simulation using axisymmetric models.
Analysis of bubble dynamics under varying acoustic amplitudes and standoff distances.
Construction of phase diagrams based on shell viscoelastic properties.

Main Results:

Wall presence minimally affects the onset of compression-only, but reduces the time to effect.
Reduced standoff distance promotes asymmetry and alters bubble oscillation shapes.
Above an amplitude threshold, compression-only interrupts entrapment; below it, trapped pulsations occur.

Conclusions:

Rigid walls significantly influence contrast agent dynamics, altering entrapment and pulsation behaviors.
Acoustic amplitude and shell properties dictate the response, from trapped pulsations to compression-only events.
Phase diagrams provide a framework for predicting microbubble behavior in ultrasound applications.