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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Updated: Jul 5, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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[Juvenile localized scleroderma].

Timmy Strauss1, Claudia Günther2, Normi Brück3

  • 1Klinik und Poliklinik für Kinder- und Jugendmedizin, Medizinische Fakultät und Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland. timmy.strauss@ukdd.de.

Dermatologie (Heidelberg, Germany)
|January 19, 2024
PubMed
Summary
This summary is machine-generated.

Juvenile localized scleroderma, a rare inflammatory skin condition, involves local sclerosis and fibrosis. Early diagnosis and specialized, multidisciplinary care are crucial for managing this childhood disease.

Keywords:
Clinical practice guidelinesJuvenile localized sclerodermaMorpheaProgressionSequelae

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Area of Science:

  • Dermatology
  • Pediatrics
  • Rheumatology

Context:

  • Juvenile localized scleroderma (JLS), also known as childhood morphea, is a rare inflammatory condition affecting the skin and underlying tissues.
  • It is characterized by localized sclerosis and tissue fibrosis, with four distinct subtypes: limited, generalized, linear, and mixed.
  • Prompt diagnosis and intervention are essential to prevent long-term complications.

Purpose:

  • To review the key clinical, laboratory, and therapeutic aspects of juvenile localized scleroderma.
  • To provide evidence-based recommendations for the management of JLS.
  • To highlight the importance of early diagnosis and specialized care.

Summary:

  • JLS presents with localized hardening and fibrosis of the skin and connective tissues.
  • Diagnosis relies on clinical presentation, with subtypes classified by pattern of involvement.
  • Treatment strategies focus on multidisciplinary approaches in specialized centers.

Impact:

  • Facilitates early identification and management of JLS, potentially reducing disease sequelae.
  • Provides a consolidated resource for clinicians managing pediatric patients with scleroderma.
  • Emphasizes the need for collaborative, specialized care to optimize patient outcomes.