Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.9K
Autoimmune Disorders01:29

Autoimmune Disorders

442
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
442
Rh Blood Group01:19

Rh Blood Group

1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Role of Musculoskeletal Ultrasound in Psoriatic Arthritis: From Preclinical Detection to Treatment Monitoring.

Current rheumatology reports·2026
Same author

Association between joint tenderness, patient-reported joint pain and ultrasound abnormalities in anti-CCP positive individuals at risk of rheumatoid arthritis: a cross-sectional study from a Leeds (UK) cohort.

BMJ open·2026
Same author

Two Patterns of Sacroiliac Joint Bone Marrow Oedema are apparent in AxSpA Determined by HLA-B27 Status, Body Mass Index or Psoriasis.

Joint bone spine·2026
Same author

A systematic approach to the consensus definitions and reliability of ultrasound in idiopathic inflammatory myopathies; Preliminary data by the OMERACT ultrasound in myositis working group.

Seminars in arthritis and rheumatism·2026
Same author

Cystatin C and Creatinine-Based Estimated GFR and Disease Activity Biomarkers in Rheumatoid Arthritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Persistent arthritis develops in joints previously affected by palindromic flares: a longitudinal study investigating the transition from palindromic rheumatism to rheumatoid arthritis.

RMD open·2026
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

149

Rheumatoid arthritis.

Andrea Di Matteo1, Joan M Bathon2, Paul Emery3

  • 1Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Carlo Urbani Hospital, Jesi, Ancona, Italy; NIHR Biomedical Research Centre, Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Lancet (London, England)
|January 19, 2024
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) is an autoimmune disease impacting joints. Advances in early diagnosis and targeted therapies have significantly improved patient outcomes, enabling more individuals to achieve disease remission.

More Related Videos

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.2K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

119

Related Experiment Videos

Last Updated: Jul 5, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

149
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.2K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

119

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease primarily affecting joints and surrounding tissues.
  • Understanding RA pathogenesis has advanced significantly, alongside developments in diagnostic and therapeutic strategies.

Purpose of the Study:

  • To provide a comprehensive overview of rheumatoid arthritis, including epidemiology, pathogenesis, clinical manifestations, and diagnostic approaches.
  • To discuss updated management and treatment recommendations from major rheumatology societies.
  • To highlight current controversies and future research directions, such as precision medicine and potential cures for RA.

Main Methods:

  • Review of epidemiological data and current understanding of RA pathogenesis.
  • Discussion of clinical features, classification criteria, and the role of imaging in diagnosis.
  • Analysis of updated treatment guidelines, including targeted therapies and combination strategies.

Main Results:

  • Significant improvements in patient outcomes and increased rates of disease remission in RA.
  • Identification of key factors contributing to better outcomes: early diagnosis, treat-to-target strategies, targeted DMARDs, and combination therapy.
  • Emergence of new medications and evolving scientific evidence necessitate continuous updates in RA diagnosis and management.

Conclusions:

  • The management of rheumatoid arthritis has evolved, with new strategies leading to improved remission rates.
  • Updated recommendations from ACR and EULAR provide guidance for optimal RA care.
  • Ongoing research is crucial for addressing controversies and exploring precision medicine, prevention, and cures for RA.