Related Experiment Video
Updated: Jul 5, 2025
09:38
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
2.1K
Vitiligo: Current Therapies and Future Treatments
Julien Seneschal1,2, Katia Boniface2
1Department of Dermatology and Pediatric Dermatology, National Reference Center for Rare Skin disorders, Hôpital Saint-André, Bordeaux, France.
Dermatology Practical & Conceptual
|January 19, 2024
Summary
Effective vitiligo management requires early intervention for active disease. Stable vitiligo treatment combines phototherapy and topical agents, with surgery for localized cases and depigmentation for extensive forms.
Area of Science:
- Dermatology
- Immunology
Background:
- Vitiligo management presents ongoing challenges.
- Early intervention is crucial for halting disease progression in active cases.
Purpose of the Study:
- To outline current and emerging treatment strategies for vitiligo.
- To provide a stratified approach to vitiligo management based on disease activity and extent.
Main Methods:
- Review of established and novel therapeutic modalities for vitiligo.
- Discussion of treatment stratification for active, stable, localized, segmental, and extensive vitiligo.
- Inclusion of recent advancements, such as topical ruxolitinib cream.
Main Results:
- Phototherapy combined with topical immunomodulatory agents is effective for stable vitiligo.
- Surgical options are suitable for localized and segmental vitiligo.
- Depigmentation is reserved for very extensive forms of vitiligo.
Conclusions:
- A multi-faceted approach tailored to disease characteristics optimizes vitiligo treatment outcomes.
- New targeted therapies, including topical ruxolitinib, represent significant advancements in vitiligo care.
- Continued research into targeted topical and oral drugs promises further improvements in vitiligo management.
More Related Videos
Related Concept Videos
01:30Skin Cancer
4.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
01:27Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
01:22iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K
01:14Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
01:30Cancer Vaccines
368
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
368
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K