URINARY TRACT INFECTIONS IN PATIENTS YOUNGER THAN 60 DAYS OLD

Area of Science:

• Pediatrics
• Infectious Diseases
• Pharmacology

Background:

• Urinary tract infections (UTIs) are common in infants.
• Parenteral antibiotics are often the standard treatment for infant UTIs.
• The optimal duration and route of antibiotic therapy require further investigation.

Purpose of the Study:

• To evaluate the safety and efficacy of switching from parenteral to oral antibiotics for UTIs in patients younger than 60 days.
• To compare clinical outcomes between infants receiving exclusively parenteral versus those transitioned to oral therapy.

Main Methods:

• Retrospective analysis of patients aged less than 60 days diagnosed with UTIs.
• Comparison of length of stay and 30-day medically attended UTI symptom recurrence between groups.
• Inclusion criteria focused on confirmed UTIs and antibiotic treatment regimens.

Main Results:

• Patients transitioned to oral antibiotic therapy demonstrated a significantly lower mean length of hospital stay.
• No statistically significant difference was observed in the rate of medically attended UTI symptoms within 30 days post-treatment between the groups.
• This suggests oral therapy is a viable option after initial parenteral treatment.

Conclusions:

• Transitioning from parenteral to oral antibiotics is a safe and effective strategy for managing UTIs in infants under 60 days.
• This approach can lead to reduced healthcare resource utilization, specifically shorter hospital stays.
• Further prospective studies could confirm these findings and optimize transition protocols.