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Using Bioluminescent Imaging to Investigate Synergism Between Streptococcus pneumoniae and Influenza A Virus in Infant Mice
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Postpandemic Rebound in Noninvasive Group a Streptococcal Disease is not Synchronous with Winter RSV and Influenza

Joana De Beir1, Miguel Lucas1, Ana Rita Jesus1

  • 1From the Paediatric Emergency Service and Infectious Diseases Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

The Pediatric Infectious Disease Journal
|January 19, 2024
PubMed

Insights

A rise in noninvasive group A Streptococcus infections occurred in 2022, coinciding with respiratory virus epidemics. This increase persisted even after viral levels declined, indicating other contributing factors are at play.

Area of Science:

  • Microbiology
  • Epidemiology
  • Infectious Diseases

Background:

  • A notable increase in invasive group A Streptococcus infections was observed in 2022.
  • This rise was initially associated with widespread circulation of respiratory viruses.

Purpose of the Study:

  • To describe the trend of noninvasive group A Streptococcus infections.
  • To investigate potential factors contributing to the observed increase in infections.

Main Methods:

  • Retrospective analysis of infection data.
  • Correlation analysis with respiratory virus circulation data.

Main Results:

  • A significant increase in noninvasive group A Streptococcus infections was identified.
  • The rise in noninvasive infections continued even after the decline of respiratory syncytial virus and influenza epidemics.

Conclusions:

  • The increase in noninvasive group A Streptococcus infections is multifactorial.
  • Factors beyond respiratory virus circulation likely contribute to the sustained rise in these infections.

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