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Perinatal exposures and adolescence overweight: The role of shared maternal-offspring pathways

Ilona Shapiro1, Iaroslav Youssim1, Ora Paltiel1

  • 1Braun School of Public Health, Hebrew University of Jerusalem, Jerusalem, 99112102, Israel.

Atherosclerosis
|January 19, 2024
PubMed

Insights

Perinatal exposures and obstetric complications independently impact adolescent overweight. Shared maternal-offspring factors influence exposure effects, but obstetric complications have independent pathways impacting offspring health.

Area of Science:

  • Reproductive health
  • Pediatric health
  • Epidemiology

Background:

  • Early life exposures significantly influence long-term offspring health.
  • Perinatal factors and obstetric complications are critical determinants of adolescent health outcomes.
  • Understanding these associations is key to developing effective interventions.

Purpose of the Study:

  • To investigate the independent associations of prevalent perinatal exposures and obstetric complications with offspring overweight in adolescence.
  • To determine if shared maternal-offspring pathways mediate the relationship between perinatal exposures and adolescent overweight.
  • To elucidate the distinct pathways through which obstetric complications affect offspring weight.

Main Methods:

  • Utilized data from the Jerusalem Perinatal Study birth cohort.
  • Constructed "obstetric complications" (OC) and "prevalent perinatal exposures" (PPE) scores.
  • Employed logistic regression to analyze associations with offspring overweight, adjusting for maternal life-course survival.

Main Results:

  • Both OC and PPE scores were independently linked to offspring overweight.
  • Maternal survival was associated with offspring overweight, but this link was weakened by the PPE score.
  • The association of OC score with offspring overweight remained significant even when maternal survival was considered.

Conclusions:

  • Shared maternal-offspring factors, reflected in maternal survival, explain the impact of prevalent perinatal exposures on offspring overweight.
  • Obstetric complications exert an independent influence on offspring overweight, suggesting additional contributing pathways.
  • These findings highlight the complex interplay of perinatal factors and maternal characteristics in shaping offspring health trajectories.
Abstract

Keywords:
Cohort studyDOHaDOverweightPerinatal exposures

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