Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

12.1K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
12.1K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

3.4K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.4K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

6.4K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.4K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

2.4K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.4K
Overview of Cell Signaling01:23

Overview of Cell Signaling

20.3K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
20.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brieflow: an integrated computational pipeline for high-throughput analysis of optical pooled screening data.

Nature communications·2026
Same author

Cell death in cancer.

Cell·2026
Same author

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy.

Molecular oncology·2026
Same author

Utilizing the predictable binding kinetics of DNA-PAINT to denoise super-resolution images.

Nature communications·2026
Same author

The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism.

eLife·2025
Same author

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.

Nature communications·2025
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026
Same journal

Structural basis for host membrane binding and remodeling by invading malaria parasites.

Cell·2026
Same journal

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026
Same journal

Arc mediates intercellular tau transmission via extracellular vesicles.

Cell·2026
Same journal

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression.

Cell·2026
See all related articles

Related Experiment Video

Updated: Jul 5, 2025

Live-Cell Fluorescence Microscopy to Investigate Subcellular Protein Localization and Cell Morphology Changes in Bacteria
05:57

Live-Cell Fluorescence Microscopy to Investigate Subcellular Protein Localization and Cell Morphology Changes in Bacteria

Published on: November 23, 2019

7.1K

Cell biology is….

Julie A Theriot, Anne Simonsen, Iva Tolić

    Cell
    |January 19, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Cell biology has evolved from a nascent field to a vast discipline. Its principles and tools are now integral to many scientific areas, reflecting its broad impact.

    More Related Videos

    Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
    10:54

    Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

    Published on: September 17, 2012

    10.5K
    Engineering Cell-permeable Protein
    21:08

    Engineering Cell-permeable Protein

    Published on: December 28, 2009

    14.5K

    Related Experiment Videos

    Last Updated: Jul 5, 2025

    Live-Cell Fluorescence Microscopy to Investigate Subcellular Protein Localization and Cell Morphology Changes in Bacteria
    05:57

    Live-Cell Fluorescence Microscopy to Investigate Subcellular Protein Localization and Cell Morphology Changes in Bacteria

    Published on: November 23, 2019

    7.1K
    Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
    10:54

    Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

    Published on: September 17, 2012

    10.5K
    Engineering Cell-permeable Protein
    21:08

    Engineering Cell-permeable Protein

    Published on: December 28, 2009

    14.5K

    Area of Science:

    • Cell Biology
    • Interdisciplinary Science

    Background:

    • Cell biology was a nascent field 50 years ago.
    • It has since grown into a vast and influential discipline.

    Purpose of the Study:

    • To explore the evolving definition of cell biology.
    • To highlight its interdisciplinary nature and impact.

    Main Methods:

    • Literature review
    • Conceptual analysis
    • Synthesis of diverse perspectives

    Main Results:

    • Cell biology's principles and tools are widely applied across disciplines.
    • Insights from other fields inspire cell biology research.

    Conclusions:

    • The definition of cell biology is multifaceted and dynamic.
    • Its interdisciplinary nature underscores its significance in modern science.