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Updated: Jul 5, 2025
Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
The role of Sirtuin 2 in liver - An extensive and complex biological process
1School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai 200438, China; Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China; Key Laboratory of Exercise and Health Sciences (Shanghai University of Sport), Ministry of Education, Shanghai 200438, China.
Abstract:
Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, and is expressed in multiple organs including liver, which plays important and complex roles by interacting with various substrates. Physiologically, Sirt2 can improve metabolic homeostasis. Pathologically, Sirt2 can alleviate inflammation, endoplasmic reticulum (ER) stress, promote liver regeneration, maintain iron homeostasis, aggravate fibrogenesis and regulate oxidative stress in liver. In liver diseases, Sirt2 can mitigate fatty liver disease (FLD) including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), but aggravate hepatitis B (HBV) and liver ischemia-reperfusion injury (LIRI). The role of Sirt2 in liver cancer and aging-related liver diseases, however, has not been fully elucidated. In this review, these biological processes regulated by Sirt2 in liver are summarized, which aims to update the function of Sirt2 in liver and to explore the potential role of Sirt2 as a therapeutic target for liver diseases.
Insights
Sirtuin 2 impacts liver health by influencing metabolic balance and disease progression. This review details its complex roles in various liver conditions, highlighting its potential as a therapeutic target.
Area of Science:
- Biochemistry
- Molecular Biology
- Hepatology
Background:
- Liver disease is a major global health concern.
- Sirtuin 2 (Sirt2) is an NAD+-dependent deacetylase found in the liver, playing multifaceted roles.
- Sirt2 influences metabolic homeostasis and pathological processes in the liver.
Purpose of the Study:
- To summarize biological processes regulated by Sirt2 in the liver.
- To update the understanding of Sirt2's function in liver health and disease.
- To explore Sirt2 as a potential therapeutic target for liver diseases.
Main Methods:
- Literature review of Sirt2's functions in the liver.
- Analysis of Sirt2's roles in various liver conditions including fatty liver disease, hepatitis, and injury.
- Synthesis of current knowledge on Sirt2's pathological and physiological effects.
Main Results:
- Sirt2 mitigates fatty liver disease (FLD), including non-alcoholic (NAFLD) and alcoholic (AFLD).
- Sirt2 aggravates hepatitis B (HBV) and liver ischemia-reperfusion injury (LIRI).
- Sirt2's roles in liver cancer and aging-related liver diseases require further elucidation.
Conclusions:
- Sirt2 exhibits context-dependent effects in liver diseases, beneficial in some and detrimental in others.
- Understanding Sirt2's dual role is crucial for developing targeted therapies.
- Further research is needed to fully elucidate Sirt2's function in liver cancer and aging.
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