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Updated: Jul 5, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Vasostatins: new molecular targets for atherosclerosis, post-ischaemic angiogenesis, and arteriogenesis
Rosalinda Madonna1, Serena Barachini2, Sandra Ghelardoni3
1Department of Surgical, Medical, and Molecular Pathology and Critical Care, University of Pisa and Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy.
Abstract:
The chromogranin-secretogranin secretory proteins-granins-are acidic proteins localized in granules of endocrine cells and neurons. The chromogranin family includes chromogranins A (CgA) and B, as well as secretogranin II (once called chromogranin C). Members of this family undergo catalytic proteolysis to produce active peptides. The CgA-derived peptides vasostatin-1 and vasostatin-2, in particular, appear to protect against atherosclerosis, suppressing the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1, as well as exerting vasodilatory effects by enhancing nitric oxide bioavailability. Vasostatin-1 also suppresses vasoconstriction and abnormal angiogenesis. Vasostatin-1 and vasostatin-2 may be novel therapeutic targets for atherosclerosis and coronary heart disease, also protecting the myocardium against ischaemic damage.
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