Plasma Oxidative State Induced by Exercise in Young Heat-Not-Burn Cigarette Users

Area of Science:

• Exercise physiology
• Oxidative stress markers
• Tobacco product comparison

Background:

• Habitual conventional cigarette (CC) smoking elevates oxidative state, a risk factor for diseases.
• Heat-not-burn cigarettes (HNBCs) are popular, and while shown to generate less oxidative stress than CC in long-term smokers, their effect on young users is unstudied.
• Previous research indicated exercise increases oxidative state in young CC smokers but not in never-smokers.

Purpose of the Study:

• To investigate resting and exercise-induced oxidative states in young HNBC users.
• To compare these oxidative states with those of young never-smokers and CC users.

Main Methods:

• Recruitment of healthy young never-smokers, HNBC users, and CC users (n=10 each).
• Participants underwent the Wingate anaerobic test.
• Plasma hydroperoxide concentration, a marker of oxidative state, was measured pre- and post-exercise.

Main Results:

• No significant differences in pre-exercise plasma hydroperoxide levels were found among the three groups.
• Exercise significantly increased plasma hydroperoxide concentration in all participants.
• HNBC users showed a significantly greater exercise-induced increase in plasma hydroperoxide compared to never-smokers (p < .005), but a significantly lower increase compared to CC users (p < .01).

Conclusions:

• HNBC use increases exercise-induced plasma oxidative state in young adults compared to never-smokers.
• This suggests that HNBC use may contribute to the risk of oxidative damage.
• The study highlights that HNBCs increase the risk of acute oxidative damage during exercise.