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Related Experiment Video

Updated: Jul 5, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19.

Lucas Scardua-Silva1,2, Beatriz Amorim da Costa1,2, Ítalo Karmann Aventurato1,2

  • 1Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), University of Campinas, Campinas, Brazil.

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Summary
This summary is machine-generated.

Mild COVID-19 survivors show persistent cognitive issues and subtle white matter changes, even without anxiety or depression. Further studies will determine if these brain alterations are temporary or permanent.

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Post-COVID-19 conditions can include neuroimaging and neuropsychological alterations.
  • Limited research exists on combined neuroimaging and neuropsychology in mild COVID-19 cases.

Purpose of the Study:

  • To investigate cognitive dysfunction and brain changes in individuals with mild COVID-19.
  • To assess white matter integrity and functional connectivity in post-mild COVID-19 patients.

Main Methods:

  • Cross-sectional study of 97 mildly infected individuals and 77 controls.
  • Utilized 3T-MRI with diffusion tensor imaging (DTI) and resting-state functional MRI (RS-fMRI).
  • Included semi-structured interviews, neurological exams, and neuropsychological assessments.

Main Results:

  • Patients reported memory loss, fatigue, and headache.
  • Confirmed fatigue, excessive somnolence, and impaired verbal fluency and memory recall.
  • DTI revealed higher axial diffusivity in white matter of post-COVID-19 patients compared to controls.
  • No significant differences in posterior cingulum cortex functional connectivity were found.

Conclusions:

  • Mild COVID-19 can lead to persistent cognitive impairment and subtle white matter abnormalities.
  • No correlation found between cognitive deficits and neuroimaging findings.
  • Longitudinal studies are needed to determine the permanence of these alterations.