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Dynamic and selective engrams emerge with memory consolidation.

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Episodic memories rely on experience-activated neuronal ensembles for encoding and recall.
  • The dynamic changes within memory engrams during consolidation remain poorly understood.

Purpose of the Study:

  • To investigate the temporal evolution of neural composition and selectivity in memory engrams.
  • To understand the role of inhibitory plasticity in memory consolidation and selectivity.

Main Methods:

  • Developed a spiking neural network model to predict engram dynamics.
  • Employed activity-dependent labeling, longitudinal calcium imaging, optogenetics, and chemogenetics in mice.
  • Conducted contextual fear conditioning experiments in the mouse dentate gyrus.

Main Results:

  • Model predicted that engrams transition from unselective to selective states via neuronal dropout and addition.
  • Inhibitory activity during recall was found essential for memory selectivity.
  • Inhibitory synaptic plasticity during consolidation critically drives engram selectivity.

Conclusions:

  • Memory engrams are not static but undergo significant dynamic changes.
  • Inhibitory plasticity plays a crucial role in mediating engram composition changes.
  • These changes are vital for the emergence and refinement of memory selectivity.