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Angiocardiographic estimation of left ventricular mass in normal infants and children
Insights
Left ventricular mass in children can be predicted using body surface area with exponential equations. These findings help differentiate normal values for anterior and posterior left ventricular mass.
Area of Science:
- Pediatric Cardiology
- Biomedical Engineering
- Medical Imaging
Background:
- Accurate assessment of left ventricular mass (LVM) is crucial for diagnosing pediatric cardiac conditions.
- Existing methods for LVM calculation may not fully account for variations in body size and cardiac wall measurements.
Purpose of the Study:
- To establish reliable predictive equations for left ventricular mass based on body surface area in infants and children.
- To investigate the relationship between left ventricular mass and left ventricular end-diastolic volume.
- To provide reference values for differentiating normal anterior and posterior left ventricular mass.
Main Methods:
- Biplane cineangiocardiograms were used to obtain left ventricular mass data from 37 healthy children.
- Left ventricular mass was calculated using anterior and posterior wall thickness.
- Data were analyzed in relation to body surface area and left ventricular end-diastolic volume.
Main Results:
- Exponential relationships were identified between left ventricular mass (anterior and posterior) and body surface area (r=0.98 and r=0.97, respectively).
- Equations derived: LVM-anterior = 68.5 (BSA) g and LVM-posterior = 84.6 (BSA) g.
- Ratios of LVM to end-diastolic volume were established: 0.73 g/ml for anterior and 0.89 g/ml for posterior LVM.
Conclusions:
- Body surface area can reliably predict left ventricular mass in children using established exponential equations.
- Distinct normal values for anterior and posterior left ventricular mass are necessary for accurate clinical interpretation.
- These predictive models enhance the non-invasive assessment of pediatric cardiac structure.
Abstract:
Left ventricular mass data were obtained from biplane cineangiocardiograms in 37 normal infants and children. Left ventricular mass calculated by using thickness of anterior wall (left ventricular mass-anterior) and posterior wall (left ventricular mass-posterior) of the free left ventricular wall were studied in relation to body surface area and left ventricular end-diastolic volume. Both of left ventricular mass-anterior and mass-posterior were expressed as a function of body surface area with exponential relationship; left ventricular mass-anterior = 68.5 (body surface area) g (r = 0.98, p less than 0.01), left ventricular mass-posterior = 84.6 (body surface area) g (r = 0.97, p less than 0.01). Left ventricular mass-anterior/left ventricular end-diastolic volume averaged 0.73 +/- 0.01 g/ml, and left ventricular mass-posterior/left ventricular end-diastolic volume 0.89 +/- 0.02 g/ml, respectively. Thus, left ventricular mass can be predicted from body surface area by using the exponential equations. In addition, normal values for left ventricular mass-posterior must be discriminated from those for left ventricular mass-anterior.