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Updated: Jul 5, 2025
10:28
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
15.2K
Transitioning from Subtyping to Precision Medicine in Parkinson's Disease: A Purpose-Driven Approach
Connie Marras1, Seyed-Mohammad Fereshtehnejad2, Daniela Berg3
1Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Summary
This study introduces a purpose-driven framework for Parkinson's disease (PD) subtyping research. It aims to guide the development and application of subtypes for precision medicine in PD patient care.
Area of Science:
- Neurology
- Movement Disorders
- Precision Medicine
Background:
- Parkinson's disease (PD) exhibits significant heterogeneity.
- Current PD subtyping approaches need refinement for precision medicine.
- A critical overview of PD subtyping research was conducted.
Purpose of the Study:
- To develop a novel, purpose-driven framework for Parkinson's disease subtyping research.
- To provide guidance for clinicians and researchers on developing, evaluating, and utilizing PD subtypes.
- To align PD subtyping with precision medicine principles.
Main Methods:
- A formal consensus methodology was employed.
- Literature review informed the framework development.
- The task force critically evaluated the PD subtyping field.
Main Results:
- Key purposes of PD subtyping were identified: predicting disease progression, predicting treatment response, and identifying therapeutic targets.
- The framework outlines desired products and research needed for each purpose.
- Purpose-driven subtyping is deemed a pragmatic step towards precision medicine in PD.
Conclusions:
- A novel framework for PD subtyping research is presented.
- This framework supports the development of subtypes for clinical trials and prognosis.
- Purpose-driven subtyping is essential for advancing precision medicine in Parkinson's disease.
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