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Influence of repeated plaque visualization on cardiovascular risk reduction after 3 years: a randomized controlled
Kristyn Whitmore1,2,3, Zhen Zhou4, Jacqueline D M Ryan5
1Baker Department of Cardiometabolic Health, The University of Melbourne, Grattan, Parkville, Victoria, 3010, Australia.
Insights
Visualizing coronary artery calcium (CAC) images in a nurse-led program significantly reduced cardiovascular risk scores and improved health markers. Repeated exposure to CAC images enhanced long-term risk control and lifestyle modifications.
Area of Science:
- Cardiology
- Preventive Medicine
- Medical Imaging
Background:
- Understanding cardiovascular (CV) risk is crucial for motivating risk reduction behaviors.
- Coronary artery calcium (CAC) imaging provides personalized risk information.
- The effectiveness of repeated CAC image visualization for sustained risk control was previously unclear.
Purpose of the Study:
- To determine if repeated visualization of CAC images sustains long-term cardiovascular risk control in primary prevention.
- To assess the impact of a nurse-led program combining CAC image visualization and statin therapy versus standard care.
Main Methods:
- A randomized trial involving asymptomatic adults aged 40-70 with a family history of premature coronary artery disease and CAC scores (1-400).
- Participants were randomized to a nurse-led CV risk reduction program with CAC image visualization and statin therapy or standard care.
- The primary outcome was the change in Framingham Risk Score (FRS) at 36 months.
Main Results:
- The intervention group showed a significantly greater reduction in FRS (difference in differences -3.4%) and LDL cholesterol compared to the control group.
- Sustained recall of CAC images within the intervention group was associated with greater reductions in systolic blood pressure and waist circumference at 36 months.
- The nurse-led program effectively initiated statin therapy in the intervention group.
Conclusions:
- A nurse-led program incorporating personalized CAC image visualization and statin therapy is effective in improving cardiovascular risk.
- Repeated visual exposure to CAC images may enhance risk reduction behaviors and outcomes.
- CAC imaging visualization can be a valuable tool in primary prevention strategies.
Aims:
Helping people to understand their cardiovascular (CV) risk can influence the choices they make for risk reduction, including medication adherence and lifestyle modification. This study sought whether repeated visualization of coronary artery calcium (CAC) images was effective in sustaining long-term risk control in primary prevention, independent of a risk reduction programme.
Methods And Results:
Asymptomatic, statin-naïve participants, 40-70 years, with a family history of premature coronary artery disease and a CAC score from 1-400 were randomized to a nurse-led CV risk reduction programme or standard care with bi-annual reviews. Only the intervention group (220 of 449 participants) visualized their CAC image (with repeat exposure in the first 3 months) and were initiated on statin therapy. The primary outcome was change in Framingham Risk Score (FRS) at 36 months, and the impact of CAC image recall on CV risk was assessed. The reduction in FRS (difference in differences (DID) -3.4% [95% CI: -4.4% to -2.4%], P ≤ 0.001 and low density lipoprotein cholesterol -1.2 mmol/L [95% CI: -1.4 to -1.0], P ≤ 0.001) over 36 months was greater in the intervention than the control group. Within the intervention group, sustained recall of CAC images at 24 months was associated with lower systolic blood pressure (DID -4.3 mmHg [95% CI: -7.7 to -0.9], P = 0.01) and waist circumference (DID -2.0 cm [95% CI: -3.9 to -0.1], P = 0.03) at 36 months compared to unsustained recall.
Conclusion:
A nurse-led programme, combining personalized patient visualization of CAC imaging with statin therapy, is beneficial for improving CV risk. Recalling the presentation of CAC images through repeated visual exposure may influence risk reduction.
Registration:
Australia New Zealand Clinical Trials Registry: ACTRN12614001294640.
Lay Summary:
This trial sought to determine whether visualization of coronary artery calcium (CAC) images influences behaviour change and cardiovascular risk reduction within a structured nurse-led programme vs. standard care. Intervention participants visualized their personalized CAC images within the first three months and commenced statin therapy. Control participants were blinded to their CAC images and were not provided statin therapy. Intervention participants had a greater absolute reduction in the Framingham Risk Score (difference in differences -3.4% [95% CI: -4.4% to -2.4%], P ≤ 0.001) compared to controls. Those with sustained recollection of their CAC images within the intervention group also had greater reductions in systolic blood pressure and waist circumference.
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