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Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...

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Related Experiment Video

Updated: Jun 16, 2026

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Recent Advances in Gut- and Gut-Organ-Axis-on-a-Chip Models.

Raehyun Kim1, Jong Hwan Sung2

  • 1Department of Biological and Chemical Engineering, Hongik University, Sejong, 30016, Republic of Korea.

Advanced Healthcare Materials
|January 20, 2024
PubMed
Summary
This summary is machine-generated.

Developing advanced in vitro gut models, like gut-on-a-chip systems, is crucial for accurate drug testing. These models mimic the human gut

Keywords:
gut‐axis‐on‐a‐chipgut‐on‐a‐chipmicrophysiological systemsmulti‐organ‐on‐a‐chip

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Area of Science:

  • Gastroenterology and Bioengineering
  • Preclinical Drug Development Models

Background:

  • The human gut is a vital organ for nutrient absorption and defense, maintaining homeostasis via complex interactions.
  • Accurate preclinical models are needed to study gut physiology and drug metabolism.
  • Current in vitro models often lack the physiological complexity of the in vivo human gut.

Purpose of the Study:

  • To review essential physiological features for accurate human gut in vitro models.
  • To highlight advancements in gut-on-a-chip and related technologies.
  • To discuss the development of multi-organ gut-on-chip systems.

Main Methods:

  • Literature review of gut-on-a-chip systems and competing technologies.
  • Analysis of key physiological features required for in vitro gut models.
  • Discussion of multi-organ system integration.

Main Results:

  • Gut-on-a-chip systems offer potential for emulating in vivo gut physiology.
  • Incorporating specific physiological features is key to improving model accuracy.
  • Multi-organ 'gut-organ-axis-on-a-chip' models are emerging.

Conclusions:

  • Physiologically relevant in vitro gut models are essential for bridging preclinical and clinical research.
  • Advanced gut models can improve drug absorption and metabolism studies.
  • Gut-on-a-chip technology shows promise for enhanced preclinical testing.