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Radiotherapy in metastatic bladder cancer
Sophie Ashley1, Ananya Choudhury1,2,3, Peter Hoskin1,2,4
1The Christie NHS Foundation Trust, Manchester, United Kingdom.
Radiotherapy effectively manages symptoms and controls disease in metastatic bladder cancer patients. Emerging evidence suggests its expanded role, particularly in oligometastatic settings combined with systemic therapies.
Area of Science:
- Oncology
- Radiation Oncology
- Urologic Oncology
Background:
- Metastatic bladder cancer presents significant challenges in symptom management and disease control.
- Radiotherapy has a long-standing role in palliative care for various cancers.
Purpose of the Study:
- To review current and emerging evidence on radiotherapy for metastatic bladder cancer.
- To assess its efficacy in symptom management and disease control.
Main Methods:
- Comprehensive literature search of PubMed and Scopus databases (1990-2023).
- Inclusion of terms: 'radiotherapy', 'palliative radiation therapy', 'metastatic bladder cancer', 'advanced bladder cancer'.
- Exclusion of non-English articles.
Main Results:
- Palliative radiotherapy effectively alleviates pain and hematuria in metastatic bladder cancer.
- Radiotherapy can consolidate treatment response by targeting oligometastatic lesions.
- Evidence from other cancers suggests radiotherapy improves quality of life and survival in oligometastatic disease without significant adverse effects.
Conclusions:
- Radiotherapy is a safe, effective, and accessible option for palliation and disease control in metastatic bladder cancer.
- Its role is expanding, especially in oligometastatic disease when combined with systemic therapies.
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