Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Breathing01:05

Breathing

59.3K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.3K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Inflammatory Response01:28

Inflammatory Response

2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dipsacoside B alleviates experimental colitis by reshaping gut microbiota and metabolically regulating the balance of macrophage polarization.

International immunopharmacology·2026
Same author

A PTPRO-Related Five-Gene Blood Transcriptional Signature with Diagnostic Potential for Tuberculosis.

Biomedicines·2026
Same author

TNF-α-mediated downregulation of CD36 and phagocytic impairment of alveolar macrophages via upregulation of ADAM17 in asthma.

Frontiers in immunology·2025
Same author

Retraction: Human Neonatal Neutrophils Are Resistant to Apoptosis with Lower Caspase-3 Activity.

The Tohoku journal of experimental medicine·2025
Same author

Regulatory mechanisms of Th9 cell differentiation.

Frontiers in immunology·2025
Same author

[Avitinib suppresses NLRP3 inflammasome activation and ameliorates septic shock in mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2025

Related Experiment Video

Updated: Jul 5, 2025

An Experimental System to Study Mechanotransduction in Fetal Lung Cells
09:35

An Experimental System to Study Mechanotransduction in Fetal Lung Cells

Published on: February 16, 2012

13.0K

Immunoregulatory function of SP-A.

Shu Dong1, Hongyuan Pang1, Fan Li1

  • 1Department of Immunology, School of Laboratory Medicine, Bengbu Medical University, Anhui 233030, China; Anhui Province Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical University, Anhui 233030, China.

Molecular Immunology
|January 20, 2024
PubMed
Summary
This summary is machine-generated.

Surfactant protein A (SP-A) is a key immune molecule in the lungs. It regulates both innate and adaptive immunity by interacting with microbes and immune cells, maintaining lung health.

Keywords:
Alveolar macrophagesLung diseaseLung homeostasisSP-ASurfactant

More Related Videos

Isolation of Lung Retinoid-Containing Cells by Cell Sorting
07:55

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

218
In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
08:54

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure

Published on: October 22, 2019

9.1K

Related Experiment Videos

Last Updated: Jul 5, 2025

An Experimental System to Study Mechanotransduction in Fetal Lung Cells
09:35

An Experimental System to Study Mechanotransduction in Fetal Lung Cells

Published on: February 16, 2012

13.0K
Isolation of Lung Retinoid-Containing Cells by Cell Sorting
07:55

Isolation of Lung Retinoid-Containing Cells by Cell Sorting

Published on: April 11, 2025

218
In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
08:54

In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure

Published on: October 22, 2019

9.1K

Area of Science:

  • Pulmonary immunology
  • Innate and adaptive immunity

Background:

  • Surfactant protein A (SP-A) is a crucial immune molecule for lung health.
  • SP-A possesses C-type carbohydrate recognition domains for binding microbial glycogroups and collagen-like regions for interacting with cell surface receptors.

Purpose of the Study:

  • To review the latest understanding of the relationships between SP-A and both adaptive and innate immunity.
  • To highlight SP-A's role in regulating lung immune responses.

Main Methods:

  • Literature review of recent studies on SP-A's immunological functions.
  • Analysis of SP-A's molecular interactions and downstream effects on immune cells.

Main Results:

  • SP-A mediates innate immunity by enhancing surfactant uptake and promoting phagocytosis of pathogens by alveolar macrophages.
  • SP-A modulates adaptive immunity by inhibiting dendritic cell maturation and suppressing T cell proliferation and differentiation.
  • SP-A interacts with various cell surface receptors including C1qRp, CRT-CD91 complex, CD14, SP-R210, Toll-like receptor, SIRP-α, and CR3.

Conclusions:

  • SP-A is a multifunctional immune regulator essential for maintaining lung homeostasis.
  • Understanding SP-A's dual role in innate and adaptive immunity provides insights into lung defense mechanisms and potential therapeutic targets.