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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Cutaneous Sarcoidosis.

Mariam Abdelghaffar1, Erica Hwang2, William Damsky3

  • 1School of Medicine, Royal College of Surgeons in Ireland, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland.

Clinics in Chest Medicine
|January 20, 2024
PubMed
Summary
This summary is machine-generated.

Sarcoidosis is a multisystem disease affecting various organs, including the skin. Dermatologic evaluation aids in diagnosing cutaneous sarcoidosis, guiding treatment based on lesion severity and patient needs.

Keywords:
AngiolupoidCutaneous sarcoidosisDarier-RoussyErythema nodosumLupus pernio

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Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Sarcoidosis is a multisystem inflammatory disease with variable organ involvement.
  • Cutaneous sarcoidosis frequently manifests as papules and plaques, often on the head and neck.
  • Early dermatologic assessment is crucial for diagnosis.

Purpose of the Study:

  • To highlight the role of dermatologic evaluation in diagnosing sarcoidosis.
  • To describe the common presentation of cutaneous sarcoidosis.
  • To outline treatment considerations for cutaneous sarcoidosis.

Main Methods:

  • Clinical presentation review of cutaneous sarcoidosis.
  • Biopsy and histopathological examination for diagnosis.
  • Assessment of lesion severity and distribution.

Main Results:

  • Cutaneous sarcoidosis presents as pink-red to red-brown papules and plaques.
  • Head and neck are common sites for skin lesions.
  • Skin biopsy is valuable for definitive diagnosis.

Conclusions:

  • Dermatologic evaluation is key for diagnosing sarcoidosis.
  • Treatment plans must consider skin lesion characteristics and other organ involvement.
  • Multidisciplinary approach is essential for comprehensive sarcoidosis management.