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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Jul 5, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Tunable Multivalent Aptamer-Based DNA Nanostructures To Regulate Multiheteroreceptor-Mediated Tumor Recognition.

Xiaoxue Hu¹, Hongli Chi², Xiaoyi Fu²

¹College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, China.

Journal of the American Chemical Society

|January 22, 2024

Summary

This study developed DNA nanostructures that precisely target tumor cells by controlling aptamer interactions. These structures enhance drug delivery and immune clearance for personalized cancer treatment.

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Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

Cell surface receptor mapping is crucial for treating diseases like cancer but presents significant challenges.
Controlling receptor interactions is key for targeted therapies.

Purpose of the Study:

To design adjustable, multivalent aptamer-based DNA nanostructures for precise control of tumor cell receptor interactions.
To develop programmable systems for enhanced targeted drug delivery and immune clearance.

Main Methods:

Profiling surface receptors on 12 cell lines using 10 aptamers to create a distinguishing heatmap.
Incorporating aptamers onto DNA origami structures (patch-like and tube-like) to regulate receptor recognition.
Investigating multiheteroreceptor-mediated recognition and its effect on cellular uptake and immune interactions.

Main Results:

A heatmap accurately distinguished tumor types based on multiple surface markers.
Tube-like nanostructures enhanced intracellular uptake via clathrin-dependent endocytosis (>5-fold increase).
Patch-like nanostructures promoted macrophage-tumor cell interactions for immune clearance.

Conclusions:

Programmable multivalent DNA nanostructures offer precise regulation of cell recognition.
This system demonstrates significant potential for personalized tumor treatment strategies.
The technology facilitates targeted drug delivery and enhances anti-tumor immunity.