Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

7.5K
7.5K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

3.5K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

3.1K
3.1K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

9.2K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

64.7K
64.7K
Base Excision Repair01:54

Base Excision Repair

3.7K
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Centralized Review of Alzheimer's Disease and Related Dementias Biomedical Repositories and Computational Methods.

Bioengineering (Basel, Switzerland)·2026
Same author

Exploring the Link Between Biotin Metabolism and <i>Brucella</i> Virulence: A Study on <i>BioA</i>.

Pathogens (Basel, Switzerland)·2026
Same author

Connexin 43 promotes stemness of leukemia cells and chemoresistance in T-cell acute lymphoblastic leukemia via the RAC1/AKT/GSK3β axis.

Chinese medical journal·2026
Same author

Distinct microbial and functional alterations across skin sites and disease severity in pediatric atopic dermatitis: a prospective study.

Frontiers in medicine·2026
Same author

Patient-reported outcomes in chronic GVHD: instruments, clinical utility, and survivorship integration.

Journal of patient-reported outcomes·2026
Same author

Relationship of Postoperative Temporary Facial Nerve Dysfunction With Tumor Location in Parotid Surgery.

Cureus·2026

Related Experiment Video

Updated: Jul 5, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.6K

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights.

Jiawei Chen1, Ravi Potlapalli2, Heng Quan3

  • 1College of Letter and Science, University of California, Berkeley, CA 94720, USA.

Biotech (Basel (Switzerland))
|January 22, 2024
PubMed
Summary

DNA damage and repair are crucial for preventing diseases like cancer. This review covers DNA repair mechanisms, computational methods, and databases, offering insights for researchers.

Keywords:
DNA damageDNA databaseDNA repair mechanismsaging-related diseasescancercomputational biologyuracil-DNA glycosylase

More Related Videos

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
09:29

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays

Published on: February 2, 2024

2.2K
Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

2.5K

Related Experiment Videos

Last Updated: Jul 5, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.6K
Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
09:29

Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays

Published on: February 2, 2024

2.2K
Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

2.5K

Area of Science:

  • Genetics and Molecular Biology
  • Bioinformatics and Computational Biology

Background:

  • DNA damage is a primary driver of genetic alterations, contributing to cancer and age-related diseases.
  • DNA repair mechanisms are essential for maintaining genomic stability and preventing disease.
  • Significant advancements in understanding DNA damage and repair have occurred in the last decade.

Purpose of the Study:

  • To provide a comprehensive review of DNA repair mechanisms, computational research methods, and databases.
  • To consolidate recent research findings in the field of DNA damage and repair.
  • To serve as a valuable resource for scientists in computational DNA research.

Main Methods:

  • Literature review consolidating research on DNA repair mechanisms.
  • Analysis of computational research methods applied to DNA damage and repair.
  • Identification and assessment of relevant databases for DNA damage and associated diseases.

Main Results:

  • Overview of major types of DNA damage and common DNA repair pathways.
  • Discussion of the availability and utility of databases for DNA damage and disease.
  • Summary of predominant computational methods used for studying DNA repair enzymes.

Conclusions:

  • This review offers the latest insights into DNA-related proteins, diseases, and methodologies.
  • It addresses key questions regarding DNA damage, repair mechanisms, and computational approaches.
  • The work is a crucial resource for researchers in computational DNA studies.