Related Experiment Video

Updated: Jul 5, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

323

The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence

Júlia Tavares E Silva1, João Pessoa1, Sandrina Nóbrega-Pereira1

  • 1Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal.

Cells
|January 22, 2024
PubMed

Insights

Regulating long non-coding RNAs (lncRNAs) shows promise in preventing cellular senescence, a key factor in aging and disease. This approach supports tissue regeneration and offers potential therapies for age-related conditions.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Cellular senescence contributes to aging and various diseases.
  • Tissue engineering offers strategies to combat senescence.
  • Long non-coding RNAs (lncRNAs) play roles in cellular processes.

Purpose of the Study:

  • To review recent studies on inhibiting cellular senescence using lncRNA modulation.
  • To explore the potential of lncRNA regulation in tissue regeneration and disease prevention.
  • To propose lncRNA-based therapies for aging and age-related diseases.

Main Methods:

  • Overview of studies involving the upregulation or downregulation of specific lncRNAs.
  • Analysis of lncRNA effects on senescence in various organs (bones, joints, nervous system, heart, blood vessels, skin, liver).
  • Examination of lncRNA's role in preventing age-related diseases like osteoarthritis, osteoporosis, neurodegenerative, and cardiovascular diseases.

Main Results:

  • lncRNA modulation successfully prevented senescence in multiple tissues.
  • This approach demonstrated potential for tissue regeneration and disease prevention.
  • Cellular rejuvenation and protection from disease were observed in skin and liver cells.
  • The findings were not limited to stem cells, highlighting broader applicability.

Conclusions:

  • lncRNA regulation is a viable strategy to inhibit cellular senescence.
  • RNA or gene therapies targeting lncRNAs offer a promising approach for preventing and treating aging and related diseases.
  • This strategy supports tissue regeneration and has broad implications for healthspan extension.
Keywords:
agingcardiovascular diseasecellular senescencedownregulationlong noncoding RNAsneurodegenerationupregulation

More Related Videos

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

8.9K
Techniques to Induce and Quantify Cellular Senescence06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.4K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.8K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.3K
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
4.9K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K