Current Advances in Regenerative Strategies for Dry Eye Diseases: A Comprehensive Review

Area of Science:

• Ophthalmology
• Biomaterials Science
• Regenerative Medicine

Background:

• Dry eye disease (DED) affects millions globally, characterized by ocular surface inflammation and tear deficiency.
• Current treatments, primarily lubricating agents, offer limited efficacy and require lifelong use.
• Severe DED can lead to corneal complications, infections, and vision loss.

Purpose of the Study:

• To explore novel therapeutic strategies for dry eye disease (DED).
• To discuss the potential of emerging treatments as long-term cures for DED.
• To analyze factors limiting the feasibility and effectiveness of these new approaches.

Main Methods:

• Review of recent scientific literature on DED treatments.
• Exploration of biomaterial-based drug delivery systems (nano-systems, hydrogels, contact lenses).
• Investigation of cell-based, biological, and tissue-based regenerative therapies.

Main Results:

• Emerging treatments show promise for more effective and sustainable DED management.
• Biomaterials, cell therapies, and regenerative approaches represent significant advancements.
• Limited effectiveness and feasibility factors require further research and development.

Conclusions:

• Novel therapeutic strategies offer hope for improved dry eye disease (DED) outcomes.
• Further research is needed to overcome limitations and establish long-term efficacy.
• Advancements in biomaterials and regenerative medicine are key to future DED treatment.