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Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor System.

Marius Gensler1, Christoph Malkmus2, Philipp Ockermann3

  • 1Department Tissue Engineering and Regenerative Medicine, University Hospital Wuerzburg, 97070 Wuerzburg, Germany.

Bioengineering (Basel, Switzerland)
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel, open-source 3D bioprinting system for regenerative medicine. The adaptable bioreactor supports cell culture and differentiation, bridging the gap from lab to clinic.

Keywords:
3D-printingadipose tissuebiofabricationbioprintingcell culture simulationperfusable bioreactor

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Tissue Engineering

Background:

  • Bioprinting enables patient-specific tissue construction for regenerative medicine.
  • Dynamic bioreactors are crucial for tissue culture and maturation.
  • Current systems often lack customizability and integration for clinical translation.

Purpose of the Study:

  • To design and validate an implant-specific, customizable bioreactor system for bioprinting.
  • To support cell cultivation and tissue maturation within a 3D-printed environment.
  • To develop an automated system for seamless integration into clinical workflows.

Main Methods:

  • Bioreactor design and simulation of shear stress and nutrient distribution for optimal cell culture.
  • Direct bioprinting of cells (C2C12 and human mesenchymal stem cells) into 3D-printed bioreactors.
  • Cell culture, differentiation of stem cells into adipocytes, and development of an automated bioreactor docking station.

Main Results:

  • Successful two-week culture of C2C12 cells in two bioinks within the designed bioreactor.
  • Demonstrated differentiation of human mesenchymal stem cells (hMSCs) towards an adipocyte lineage.
  • Development of a prototype automated mobile docking station for the bioreactor system.

Conclusions:

  • An open-source, adaptable bioreactor system for bioprinting has been developed.
  • The system facilitates cell culture and differentiation, crucial for regenerative medicine applications.
  • This integrated approach aims to accelerate the clinical translation of 3D bioprinting technologies.