Related Experiment Video

Updated: Jul 5, 2025

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

12.3K

Novel Therapeutics in Ovarian Cancer: Expanding the Toolbox

Sara Moufarrij1, Roisin E O'Cearbhaill2,3

  • 1Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Current Oncology (Toronto, Ont.)
|January 22, 2024
PubMed

Insights

Most ovarian cancer patients recur and develop treatment resistance. Novel therapies, including targeted agents and immunotherapies, are improving outcomes for recurrent ovarian cancer.

Area of Science:

  • Gynecologic Oncology
  • Cancer Therapeutics
  • Immunotherapy

Background:

  • Ovarian cancer frequently recurs despite initial treatment.
  • Acquired resistance to standard therapies is a major challenge.
  • The tumor immune microenvironment significantly impacts treatment response.

Purpose of the Study:

  • To review current and emerging therapies for ovarian cancer.
  • To explore novel strategies targeting drug resistance and immune modulation.
  • To discuss innovative combination therapies for recurrent disease.

Main Methods:

  • Literature review of chemotherapy, targeted agents, and immunotherapies.
  • Analysis of novel therapeutic targets like DNA repair inhibitors and antibody-drug conjugates.
  • Exploration of immunotherapeutic agents including interleukins, oncolytic viruses, and cancer vaccines.

Main Results:

  • Targeted agents (PARP inhibitors, bevacizumab, mirvetuximab) show promise.
  • Novel antibody-drug conjugates and DNA repair inhibitors offer new avenues.
  • Immunotherapies (interleukins, oncolytic viruses, vaccines) are emerging.
  • Combination therapies are driving a rapidly evolving treatment landscape.

Conclusions:

  • Innovative therapies are crucial for overcoming resistance in ovarian cancer.
  • Targeting oncogenic pathways and the immune microenvironment is key.
  • Combination strategies hold significant promise for improving patient outcomes.
Keywords:
antibody–drug conjugatecheckpoint inhibitionhomologous recombination deficiencymonoclonal antibodynanoparticleoncolytic virusesovarian cancerpoly (ADP-ribose) polymerase inhibitionresistancevaccines

More Related Videos

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-107:59

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

Published on: December 5, 2020

2.6K
Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer09:40

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

Published on: August 2, 2024

2.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
368
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K