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AG1® Induces a Favorable Impact on Gut Microbial Structure and Functionality in the Simulator of Human Intestinal
Trevor O Kirby1, Philip A Sapp1, Jeremy R Townsend1,2
1Research, Nutrition, and Innovation, Athletic Greens International, Carson City, NV 89701, USA.
Current Issues in Molecular Biology
|January 22, 2024
Summary
The foundational nutrition supplement AG1® significantly impacts gut microbial composition and function in vitro. These changes in the human gut microbiome may lead to beneficial health effects.
Area of Science:
- Microbiology
- Nutraceutical Science
- Gut Microbiome Research
Background:
- The human gut microbiome plays a crucial role in health and is a target for nutraceutical interventions.
- Understanding how supplements affect gut microbiota is essential for developing effective health strategies.
Purpose of the Study:
- To investigate the effects of the foundational nutrition supplement AG1® on human gut microbiota composition and function.
- To assess changes in microbial community structure and metabolic pathways using an in vitro model.
Main Methods:
- Utilized the Simulator of Human Intestinal Microbial Ecosystem (SHIME®) model for in vitro digestion, absorption, and colonic simulation.
- Employed shallow shotgun, whole genome sequencing for metagenomic analysis of gut microbiota.
- Analyzed changes in alpha diversity, beta diversity, specific taxa, functional heterogeneity, and metabolic pathways.
Main Results:
- No significant alteration in alpha diversity was observed.
- A significant treatment and donor effect, along with an interaction, was found on structural heterogeneity, driven by eight enriched bacterial taxa.
- Community functional heterogeneity was also significantly affected, with 20 metabolic pathways showing enrichment.
Conclusions:
- An acute dose of AG1® demonstrably alters gut microbial composition and function in vitro.
- These findings suggest potential favorable effects on the human gut microbiome and host health.
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