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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

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Postoperative Coagulation Changes in Patients after Epicardial Left Atrial Appendage Occlusion Varies Based on the

Jakub Batko1,2, Jakub Rusinek1, Artur Słomka2,3

  • 1CAROL-Cardiothoracic Anatomy Research Operative Lab, Department of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College, 31-008 Krakow, Poland.

Diseases (Basel, Switzerland)
|January 22, 2024
PubMed

Insights

Left atrial appendage occlusion improves systemic coagulation. Patients with smaller left atrial appendages may experience greater benefits in stabilizing clotting factors, potentially reducing future thromboembolic events.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Devices

Background:

  • Left atrial appendage occlusion (LAAAO) influences systemic coagulation.
  • Understanding coagulation factor changes post-LAAAO is crucial for patient outcomes.
  • LAA morphology may impact these systemic changes.

Purpose of the Study:

  • To investigate differences in coagulation factor changes 6 months after epicardial LAAAO.
  • To analyze the relationship between LAA morphometry and coagulation factor alterations.
  • To determine if LAA size influences the benefits of LAA closure on coagulation.

Main Methods:

  • Prospective study of 22 consecutive patients undergoing epicardial LAAAO.
  • Coagulation parameters (plasminogen, fibrinogen, tPA, PAI-1, TAFI) and CT angiograms were assessed.
  • Patients were subgrouped based on LAA body and orifice diameter enlargement.

Main Results:

  • In patients with normal LAA size, most clotting factors significantly decreased post-occlusion.
  • Patients with enlarged LAA bodies showed decreased clotting factors, except for plasminogen (increased) and TAFI (no significant change).
  • LAA occlusion demonstrated a beneficial effect on systemic coagulation.

Conclusions:

  • Left atrial appendage occlusion is beneficial for systemic coagulation.
  • Patients with smaller LAA morphology may derive greater benefits from LAA closure.
  • Stabilization of coagulation factors post-LAAAO may reduce future thromboembolic risks.

Keywords:
LARIATatrial fibrillationcoagulationcoagulation factorsleft atrial appendageleft atrial appendage anatomyleft atrial appendage occlusionthrombolysis

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