Related Experiment Video

Updated: Jul 5, 2025

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.0K

Management of Acute Bronchiolitis in Spoke Hospitals in Northern Italy: Analysis and Outcome

Carla Guidi1, Neftj Ragusa2, Ilaria Mussinatto3

  • 1Pediatrics Department, Ciriè Hospital, 10073 Ciriè, TO, Italy.

Diseases (Basel, Switzerland)
|January 22, 2024
PubMed

Insights

Bronchiolitis management in infants improved with high-flow nasal cannula (HFNC) oxygen therapy, reducing hospital transfers. This study analyzed pediatric cases, showing HFNC

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Bronchiolitis is a common acute viral lower respiratory tract infection in infants.
  • Respiratory syncytial virus (RSV) is the primary cause, but other viruses can also be involved.
  • Effective management strategies are crucial for reducing hospitalization and complications.

Purpose of the Study:

  • To retrospectively analyze clinical features and treatment outcomes of hospitalized infants with acute bronchiolitis.
  • To evaluate the effectiveness of high-flow nasal cannula (HFNC) oxygen support in managing bronchiolitis.
  • To identify factors associated with the need for transfer to a hub referral hospital.

Main Methods:

  • Retrospective review of clinical data from infants <12 months hospitalized for bronchiolitis over two seasons.
  • Analysis of patient-, disease-, and treatment-related variables.
  • Comparison of outcomes between RSV and non-RSV cases and assessment of HFNC use.

Main Results:

  • Overall therapeutic success (discharge home) was 96% (93% for RSV, 98% for non-RSV).
  • High-flow nasal cannula (HFNC) was used in 22% of 192 infants; only 4% required hub hospital transfer.
  • Factors associated with hub transfer included age <1 month and HFNC failure.

Conclusions:

  • High-flow nasal cannula (HFNC) significantly improved bronchiolitis management in spoke hospitals, reducing the need for intensive care unit transfers.
  • HFNC is an effective intervention for hospitalized infants with bronchiolitis, particularly in non-hub facilities.
  • Early identification of infants at risk for transfer (e.g., <1 month old, HFNC failure) is important for timely escalation of care.

Keywords:
bronchiolitischildrenhigh flow nasal cannularespiratory syncytial virus

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K
Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

897

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
331
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
141
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.1K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
227
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
208
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.6K