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A Novel Acetone Sensor for Body Fluids.

Oscar Osorio Perez1,2, Ngan Anh Nguyen1,2, Asher Hendricks1,2

  • 1School of Engineering for Matter, Transport and Energy, Arizona State University, Tempe, AZ 85287, USA.

Biosensors
|January 22, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel breath acetone sensor for monitoring fat oxidation. The device offers a sensitive, selective, and stable method for ketone monitoring, overcoming limitations of current approaches.

Keywords:
breath sensordigital medicinefat burningfat oxidationketonesmetabolic ratepoint of carewearable sensor

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Area of Science:

  • Biochemistry
  • Biomarkers
  • Medical Devices

Background:

  • Ketones, including blood/urine acetoacetic acid and beta-hydroxybutyric acid, are key biomarkers of fat oxidation.
  • Monitoring ketone levels is crucial for weight management and ketogenic therapies.
  • Existing methods for ketone monitoring (urine, blood, breath) have significant limitations.

Purpose of the Study:

  • To develop and validate a novel sensor device for detecting acetone in breath.
  • To overcome the drawbacks associated with current ketone monitoring technologies.
  • To provide a convenient and accurate method for assessing fat oxidation via breath analysis.

Main Methods:

  • Development of a novel acetone sensor utilizing a complementary metal oxide semiconductor (CMOS) chip.
  • Implementation of a red, green, and blue deconvolution imaging approach for data analysis.
  • Validation of the sensor device using real breath samples and comparison with a blood ketone reference method.

Main Results:

  • The novel sensor demonstrated high sensitivity in the micromolar-concentration range.
  • The device exhibited excellent selectivity for acetone detection in breath.
  • The sensor maintained stability for at least one month of use.

Conclusions:

  • The developed acetone sensor offers a promising, non-invasive method for monitoring fat oxidation.
  • This technology addresses the limitations of existing ketone monitoring tools.
  • The device shows potential for widespread use in weight management and therapeutic ketogenic applications.